Stefania Noerman Olli Kärkkäinen Anton Mattsson Jussi Paananen Marko Lehtonen Tarja NurmiTomi‐Pekka Tuomainen Sari Voutilainen Kati Hanhineva Jyrki K Virtanen

First published: 12 December 2018

https://doi.org/10.1002/mnfr.201800605

Scope

Higher egg intake was previously associated with a lower risk of developing type 2 diabetes (T2D) in the prospective, population‐based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in eastern Finland. Potential compounds that can explain this association are explored using nontargeted LC‐MS‐based metabolic profiling.

Methods and results

Two hundred and thirty‐nine baseline serum samples from the KIHD are analyzed in four groups: subjects with higher (mean intake one egg per day) or lower (mean intake two eggs per week) egg intake who developed T2D (cases) or remained heatlhy (controls) during the mean follow‐up of 19.3 years. Different serum profiles of subjects who had either higher or lower egg intakes, and of those who developed type 2 diabetes or remained healthy, are observed. The higher baseline tyrosine level predicts higher odds of T2D (OR 1.94; 95% CI 1.45, 2.60; p < 0.001; FDR 0.023) along with an unknown hexose‐containing compound (OR 2.13; 95% CI 1.57, 2.88; p < 0.001; FDR 0.005). Certain predominant metabolites in T2D cases are correlated positively with ones in the lower‐egg‐intake group and negatively with ones in the higher‐egg‐intake group.

Conclusion

Our current findings may underline some potential metabolites that can explain how egg intake is associated with a lower risk of T2D.